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ASP Isotopes is a technology company focused on the production and supply of critical isotopes for various sectors, including nuclear medicine, semiconductors, and nuclear fuel. With a strong emphasis on advanced production technologies, the company aims to meet the rising global demand for medical isotopes, particularly in cancer diagnosis and treatment.

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Opportunity to be one of the few producers in the undersupplied global medical isotopes market, which is anticipated to grow from $6.74bn in 2024, to $13.67 bn by 2033, growing at a CAGR of 8.2%. This will be driven by increasing prevalence of cancers, rising demand for personalised medicine, and growing technological advancements in diagnostic imaging modalities.

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The global semiconductor market is on track to surpass $1tn by 2030. ASPI is partnering with the global semiconductor industry to supply large quantities of Silicon-28 through 2030 and beyond to allow the industry to unlock the significant performance (speed and heat reduction) benefits that arise from switching to Silicon-28 Nanowires

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ASPI’s wholly owned subsidiary, “Quantum Leap Energy” (”QLE”), is looking to address the multi-billion-dollar opportunity in the nuclear sector, by applying its Quantum Enrichment technology to become the only Western-aligned, low-cost producer of nuclear fuel for next-generation reactors.

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Commercial Production

ASPI is going into commercial production at multiple plants in H1'25 and will start to generate revenues at highly attractive gross margins.

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Global Expansion

ASPI is looking to build its next generation plants in Iceland to leverage significantly lower electricity costs and further improve margins. Additionally, it is looking at commercialising its Quantum Enrichment technology in South Africa at some point in 2025.

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Powering the Next Generation

ASPI believes it has the technology to enter the nuclear fuel market and provide the nuclear fuel to power the next generation of nuclear reactors. Bill Gates' nuclear company, TerraPower, has partnered with ASPI to fuel its next-gen reactors. The longer-term vision for this project will be to take depleted uranium (nuclear waste), and re-enrich it to various levels of fuel (LEU, LEU+, HALEU).

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The QLE enrichment method has not been applied to uranium since the 1980s, and while management is optimistic that the Quantum Enrichment process, coupled with vastly improved technology (lasers), will provide a basis for commercialisation, this is in no way guaranteed and as such production timelines could be extended.

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While conversations are advancing with various governments, entering new markets, particularly in the nuclear sector, can be a highly bureaucratic and time-consuming process, which might negatively impact production timelines. Other potential licensing risks could include supply-chain components such as transport, import or export licenses for key equipment such as lasers.

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Given the technical nature of ASPI and QLE operations, there are many specialist personnel including but not limited to engineers, scientists, mathematicians, and physicians. Worth highlighting is that the Company currently has a 100% retention rate for its employees but should key personnel stop working for the Company for whatever reason, this too could negatively impact production timelines and commercial viability of various products.

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ASPI currently have contracts signed for Si-28 (semiconductors), C-14 (medical tracing), and Ytterbium-176 (pluvicto). They have seen more short-term demand for Si-28 than expected and are planning to focus a significant portion of resources to this opportunity. It is also well documented that isotopes relevant for nuclear medicine are undersupplied so there are various opportunities here. Longer term, the largest end market for is uranium, specifically high-assay low-enriched uranium for next-generation nuclear reactors. ASPI via its wholly owned subsidiary, Quantum Leap Energy (\"QLE\") is hoping to become the only scalable, low-cost producer outside of Russia for this fuel type.

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While ASPI technology has been proven at commercial scale for some isotopes, there is some technological risk with scaling production in other products. In addition, ASPI do not have extensive experience in building plants and highlight the possibility of supply chain fragility given reliance on third parties for component parts of their plants.

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Most single isotope plants cost between $5-20m using ASP technology and $2.5-20 for Quantum Enrichment. Scaling uranium production will require multiple vessels but ASPI are comfortable saying >$100m.

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QLE will focus on the nuclear fuels of the future, and therefore presents a completely different customer base to that of ASP end markets. In addition, having the companies as separate entities will help discussions with various regulators. As previously announced, the intention is for ASPI to spin-off QLE at some point in 2025. The current guidance given by the company is for commercial scale production to start in 2027. However, this is dependent on technological readiness and a license from one of the three countries where they have applied (South Africa, US, UK).

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